Shanghai Institute of Neurosurgery, Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Arch Phys Med Rehabil. 2011 Sep;92(9):1515-8. doi: 10.1016/j.apmr.2011.01.014. Epub 2011 May 26.
Paroxysmal sympathetic hyperactivity (PSH) after severe brain injury is detrimental to the recovery of patients. Pharmacologic management of PSH is difficult and efficacy is unpredictable or incomplete. This report presents 6 cases of PSH after extremely severe traumatic brain injury in which hyperbaric oxygen therapy (HBOT) controlled paroxysmal autonomic changes and posturing in the early subacute phase after limited success with conventional medication regimens. Thus, HBOT may present an option for the management of PSH in addition to pharmacologic therapy. Potential mechanisms for these effects are discussed.
严重脑损伤后的阵发性交感神经兴奋（PSH）不利于患者的恢复。PSH 的药物治疗困难，疗效不可预测或不完全。本报告介绍了 6 例特重创伤性脑损伤后 PSH 患者，高压氧治疗（HBOT）在常规药物治疗方案有限成功后早期亚急性期控制阵发性自主改变和姿势，因此，HBOT 可能是药物治疗外治疗 PSH 的一种选择。讨论了这些影响的潜在机制。
