Department of Psychiatry, Yale University, 300 George Street, New Haven, CT 06511, USA.
Psychiatry Res. 2011 Aug 15;188(3):453-5. doi: 10.1016/j.psychres.2011.05.009. Epub 2011 May 26.
This pilot study tested whether posttraumatic stress disorder (PTSD) patients with impaired conditioned fear acquisition were refractory to open-label duloxetine treatment. Patients with a differential conditioned fear response at pre-treatment subsequently demonstrated significant reductions in PTSD symptoms. These data provide initial evidence of a putative biomarker of selective treatment response in PTSD.
本初步研究旨在检验创伤后应激障碍（PTSD）患者是否存在条件性恐惧习得障碍，且对开放标签度洛西汀治疗无反应。在治疗前表现出不同条件性恐惧反应的患者，其 PTSD 症状随后出现显著减轻。这些数据为 PTSD 选择性治疗反应的潜在生物标志物提供了初步证据。
