Foreman M M, Wernicke J F
Lilly Research Laboratory, Lilly Corporate Center, Indianapolis, IN 46285.
Semin Urol. 1990 May;8(2):107-12.
Currently, there are no effective oral drug therapies for the treatment of sexual dysfunction. The intent of this review was to outline the new research strategies that have emanated from experimental and clinical observations. These strategies include pharmacologic modification of cellular responses within the ventral diencephalon, brain stem, spinal cord, and penis, which represent segments of the erectile response systems. Although it is theoretically possible to treat sexual dysfunction by targeting any one of these segments, a single approach would most likely benefit only a subgroup of patients. Erectile dysfunction patients may have characteristics of several disorders, in which case combined drug therapies may be more useful. The goal of the current research is to define the regulation of sexual function at each segment of the response loop and to apply this knowledge to the treatment of the diverse disorders that contribute to erectile dysfunction.
目前，尚无有效的口服药物疗法用于治疗性功能障碍。本综述的目的是概述从实验和临床观察中产生的新研究策略。这些策略包括对腹侧间脑、脑干、脊髓和阴茎内细胞反应进行药理学调节，这些部位代表勃起反应系统的各个部分。虽然从理论上讲，针对这些部位中的任何一个进行治疗都有可能治疗性功能障碍，但单一方法很可能仅对部分患者有益。勃起功能障碍患者可能具有几种病症的特征，在这种情况下，联合药物疗法可能更有用。当前研究的目标是确定反应回路各部分性功能的调节机制，并将这一知识应用于治疗导致勃起功能障碍的各种病症。
