Rosen R C, Ashton A K
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Department of Psychiatry, Piscataway 08854-5635.
Arch Sex Behav. 1993 Dec;22(6):521-43. doi: 10.1007/BF01543299.
The search for an effective aphrodisiac has been a perennial pursuit of most societies throughout history. In the past decade, attention has focused increasingly on the prosexual effects of oral pharmacological agents with central neurotransmitter actions. The role of various dopaminergic, adrenergic, and serotonergic agents, in particular, has been intensively investigated in both human and animal studies. Some of these drugs have been considered for their potential role in the treatment of sexual dysfunction, while others have contributed to our understanding of basic neurophysiological processes in sexual arousal. This review provides a critical evaluation of current laboratory and clinical research on the "new aphrodisiacs," including studies in both patient populations and normal volunteers. Several conceptual and methodological problems are addressed, such as the definition and measurement of sexual response, the need to separate specific and nonspecific drug effects on sexual response, and the lack of studies in women. Although no single drug has proven to be clinically safe and reliably effective for human use, several promising candidates have been identified. Overall, research on prosexual drugs has contributed significantly to our understanding of basic mechanisms in sexual response, as well as providing new treatment options for common sexual disorders.
纵观历史，多数社会长期以来都在探寻有效的催情剂。在过去十年里，人们越来越关注具有中枢神经递质作用的口服药理制剂的性促进作用。尤其是各种多巴胺能、肾上腺素能和5-羟色胺能制剂的作用，在人体和动物研究中都得到了深入探究。其中一些药物因其在治疗性功能障碍方面的潜在作用而受到关注，而其他一些药物则有助于我们理解性唤起中的基本神经生理过程。这篇综述对当前关于“新型催情剂”的实验室和临床研究进行了批判性评估，包括对患者群体和正常志愿者的研究。文中探讨了几个概念和方法上的问题，比如性反应的定义和测量、区分药物对性反应的特异性和非特异性作用的必要性，以及针对女性的研究匮乏。尽管尚未有单一药物被证明对人类使用在临床上是安全且可靠有效的，但已确定了几种有前景的候选药物。总体而言，对性促进药物的研究极大地增进了我们对性反应基本机制的理解，同时也为常见性功能障碍提供了新的治疗选择。
