Dipartimento di Fisiopatologia, Medicina Sperimentale e Sanità Pubblica, Università di Siena, Viale Aldo Moro, Italy.
J Steroid Biochem Mol Biol. 2011 Sep;126(3-5):57-64. doi: 10.1016/j.jsbmb.2011.05.006. Epub 2011 May 19.
Hexose-6-phosphate dehydrogenase (H6PD) is the main NADPH generating enzyme in the lumen of the endoplasmic reticulum. H6PD is regarded as an ancillary enzyme in prereceptorial glucocorticoid activation and probably acts as a nutrient sensor and as a prosurvival factor. H6PD expression was determined in a variety of rat and human tissues by detecting mRNA and protein levels, and by measuring its dehydrogenase and lactonase activities. It was found that H6PD was present in all investigated tissues; both expression and activity remained within an order of magnitude. Correlation was found between the dehydrogenase activity and protein or mRNA levels. The results confirmed the supposed housekeeping feature of the enzyme.
己糖-6-磷酸脱氢酶（H6PD）是内质网腔中生成 NADPH 的主要酶。H6PD 被认为是糖皮质激素前受体激活的辅助酶，可能作为营养传感器和生存促进因子发挥作用。通过检测 mRNA 和蛋白质水平以及测量其脱氢酶和内酯酶活性，确定了各种大鼠和人类组织中的 H6PD 表达情况。结果发现 H6PD 存在于所有研究的组织中；表达和活性都保持在数量级内。脱氢酶活性与蛋白质或 mRNA 水平之间存在相关性。这些结果证实了该酶的管家特征。
