Study Group Clinical fMRI, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.
Neuroimage. 2011 Aug 1;57(3):1015-21. doi: 10.1016/j.neuroimage.2011.05.010. Epub 2011 May 17.
Despite there being an increasing number of installations of ultra high field MR systems (>3T) in clinical environments, no functional patient investigations have yet examined possible benefits for functional diagnostics. Here we performed presurgical localization of the primary motor hand area on 3T and 7T Siemens scanners with identical investigational procedures and comparable system specific sequence optimizations. Results from 17 patients showed significantly higher functional sensitivity of the 7T system measured via percent signal change, mean t-values, number of suprathreshold voxels and contrast to noise ratio. On the other hand, 7T data suffered from a significant increase of artifacts (ghosting, head motion). We conclude that ultra high field systems provide a clinically relevant increase of functional sensitivity for patient investigations.
尽管在临床环境中安装超高场磁共振系统（>3T）的数量不断增加，但尚未有任何功能患者调查研究检查超高频磁共振系统在功能诊断方面的潜在益处。在这里，我们使用相同的研究程序和可比的系统特定序列优化，在西门子 3T 和 7T 扫描仪上对原发性运动手区进行了术前定位。17 名患者的结果表明，通过信号变化百分比、平均 t 值、超阈值体素数量和对比噪声比来衡量，7T 系统的功能灵敏度显著更高。另一方面，7T 数据受到伪影（重像、头部运动）显著增加的影响。我们的结论是，超高场系统为患者研究提供了临床相关的功能灵敏度的提高。
