Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
J Formos Med Assoc. 2011 May;110(5):336-41. doi: 10.1016/S0929-6646(11)60050-8.
Immunogenicity and reactogenicity of primary vaccination with combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus (DTPa-HBV-IPV) vaccine when co-administered with Haemophilus influenzae (Hib) conjugate vaccine were assessed in 60 healthy infants. Infants received HBV vaccine at birth, then DTPa-HBV-IPV and Hib vaccines at age 1.5 months, 3.5 months and 6 months. Blood samples were collected before the first DTPa-HBV-IPV and Hib vaccine doses and 1 month after dose 3. Reactogenicity was assessed using diary cards. One month after primary vaccination, all infants were seroprotected/seropositive against all vaccine antigens evaluated. The poliovirus antigen could not be evaluated. The vaccines were well tolerated. No case of fever > 39.0 °C was reported. No serious adverse events were considered related to vaccination. Primary vaccination with DTPa-HBV-IPV and Hib vaccines was immunogenic and well tolerated. Combined vaccines, such as this pentavalent vaccine, minimize the number of injections and vaccination visits required to complete primary vaccination, and provide choice and flexibility for physicians and vaccine providers.
在 60 名健康婴儿中评估了联合使用白喉、破伤风、无细胞百日咳、乙型肝炎（DTaP-HBV-IPV）疫苗和流感嗜血杆菌（Hib）结合疫苗进行初级免疫接种的免疫原性和反应原性。婴儿在出生时接种乙肝疫苗，然后在 1.5 个月、3.5 个月和 6 个月时接种 DTaP-HBV-IPV 和 Hib 疫苗。在第一次 DTaP-HBV-IPV 和 Hib 疫苗接种前和接种后 3 个月采集血样。使用日记卡评估反应原性。初级免疫接种一个月后，所有婴儿对所有评估的疫苗抗原均具有保护性/阳性血清反应。无法评估脊髓灰质炎病毒抗原。疫苗耐受性良好。未报告发热>39.0°C 的病例。未认为任何严重不良事件与接种有关。DTaP-HBV-IPV 和 Hib 疫苗的初级免疫接种具有免疫原性且耐受性良好。联合疫苗，如这种五价疫苗，可最大限度地减少完成初级免疫接种所需的注射次数和接种次数，并为医生和疫苗提供者提供选择和灵活性。
