Vernalis (R&D) Ltd., Granta Park, Great Abington, Cambridge CB21 6GB, United Kingdom.
Bioorg Med Chem Lett. 2011 Jul 1;21(13):4032-5. doi: 10.1016/j.bmcl.2011.04.132. Epub 2011 May 11.
A series of N-formyl hydroxylamine peptide deformylase inhibitors containing a cyclic azaamino acid moiety between the P1' and P3' substituents are presented. Selected compounds display antibacterial activity against pathogens associated with respiratory tract infections with representative compounds showing excellent MICs against Haemophilus influenzae.
本文介绍了一系列含有 P1' 和 P3' 取代基之间的环状氮杂氨基酸部分的 N-甲酰基羟胺肽脱甲酰基酶抑制剂。部分选定的化合物对与呼吸道感染相关的病原体具有抗菌活性，代表性化合物对流感嗜血杆菌具有优异的 MIC 值。
Zotero 插件