Locker A P, Horrocks C, Gilmour A S, Ellis I O, Dowle C S, Elston C W, Blamey R W
Professional Unit of Surgery, Nottingham City Hospital, UK.
Br J Surg. 1990 May;77(5):564-7. doi: 10.1002/bjs.1800770533.
Using archival paraffin wax embedded tumour we have investigated histological grade, DNA ploidy, S phase fraction and proliferative index in 74 patients with symptomatic ductal carcinoma in situ (DCIS) of the breast. Nine patients developed local recurrence, six invasive in character. No patients with the cribriform subtype of DCIS developed local recurrence. The cribriform subtype showed a significantly lower rate of DNA aneuploidy and a lower proliferative index than the other subtypes. Cribriform tumours were almost exclusively well differentiated in contrast with the comedo and solid variants. Our results suggest the cribriform variant is less aggressive than other subtypes of DCIS. This has possible implications for management of these lesions.
我们利用存档的石蜡包埋肿瘤，对74例有症状的乳腺导管原位癌（DCIS）患者的组织学分级、DNA倍体、S期分数和增殖指数进行了研究。9例患者出现局部复发，其中6例具有浸润性特征。DCIS筛状亚型的患者均未发生局部复发。与其他亚型相比，筛状亚型的DNA非整倍体率显著较低，增殖指数也较低。与粉刺样和实体样变体相比，筛状肿瘤几乎均为高分化。我们的结果表明，筛状变体的侵袭性低于DCIS的其他亚型。这可能对这些病变的管理具有启示意义。
