Nwokocha C R, Ufearo C S, Owu D U, Idemudo N C, Ojukwu L C
Department of Basic Medical Sciences, University of the West Indies Mona Jamaica, West Indies.
Toxicol Ind Health. 2012 Mar;28(2):131-5. doi: 10.1177/0748233711407955. Epub 2011 May 27.
The resultant effects of lead exposure are seen in almost all the systems of the body and results in toxicity to many organs. Since toxicity depends on its degree of uptake, distribution and metabolism, the authors investigated the differential uptake, accumulation and distribution of lead in organs of males and female Wistar rats following various routes of administration. Group 1 served as control male and control female; group 2 males and females received 5 mg/kg body weight of lead intraperitoneally for 8 days while group 3 males and female rats were administered drinking water containing 100 ppm of lead acetate for 18 days. Tissues were collected for analysis of the lead content using atomic absorption spectroscopy. The relative retention of lead by the tissues was greater in rats exposed to lead by the i.p. route varying in the order of accumulation / uptake in males as lungs > spleen > stomach > kidney > blood > heart and in females as spleen > stomach > heart > kidney > blood > lungs (i.p. route) and (oral route) as for males kidney > lungs > stomach > blood > heart > spleen, and females as kidney > lungs > stomach > blood > heart > spleen. Male Wistar rats showed more accumulation with oral exposure in lungs, spleen and blood with values for kidney and stomach being significantly (p < 0.05) higher when compared with females. Female Wistar rats showed more accumulation with i.p. exposure for spleen and stomach tissues while values for the heart was significantly (p < 0.05) higher than the males. Our findings suggest that lead retention and the organ distribution varied depending upon the sex and route of lead administration.
铅暴露的最终影响几乎在人体的所有系统中都能看到，并导致对许多器官产生毒性。由于毒性取决于其摄取、分布和代谢程度，作者研究了不同给药途径后雄性和雌性Wistar大鼠器官中铅的差异摄取、积累和分布情况。第1组为雄性和雌性对照；第2组的雄性和雌性大鼠腹腔注射5 mg/kg体重的铅，持续8天，而第3组的雄性和雌性大鼠饮用含100 ppm醋酸铅的水，持续18天。收集组织，使用原子吸收光谱法分析铅含量。腹腔注射途径暴露于铅的大鼠组织中铅的相对保留量更大，雄性的积累/摄取顺序为肺>脾>胃>肾>血液>心脏，雌性为脾>胃>心脏>肾>血液>肺（腹腔注射途径），口服途径（雄性为肾>肺>胃>血液>心脏>脾，雌性为肾>肺>胃>血液>心脏>脾）。雄性Wistar大鼠经口暴露后，肺、脾和血液中的积累更多，与雌性相比，肾和胃中的值显著更高（p<0.05）。雌性Wistar大鼠经腹腔注射暴露后，脾和胃组织中的积累更多，而心脏中的值显著高于雄性（p<0.05）。我们的研究结果表明，铅的保留和器官分布因铅的给药性别和途径而异。
