Amano S, Hazama F, Haebara H, Tsurusawa M, Kaito H
Acta Pathol Jpn. 1978 Sep;28(5):721-30. doi: 10.1111/j.1440-1827.1978.tb00911.x.
An autopsy case of a 9-year-old Japanese girl revealed a carcinoid tumor originating in the duodenum and hyperplasia of the multiple endocrine organs as manifested by ectopic ACTH syndrome, carcinoid syndrome and giantism. The tumor cells were positive for histochemical argyrophile reaction and two types of secretory granules were identified by electron microscopy. Biochemical assay revealed the production of ACTH and beta-MSH by the tumor cells. Other changes of multiple endocrine organs included acidophil dominant hyperplasia of the pituitary, diffuse hyperplasia of the thyroid, chief cell hyperplasia of the parathyroid, hyperplasia of the islets of Langerhans and the adrenal cortex. This case was considered to be a type of multiple endocrine adenomatosis including carcinoid tumor. The relationship between the carcinoid tumor and multiple endocrine adenomatosis was discussed.
一名9岁日本女孩的尸检病例显示，十二指肠发生类癌肿瘤，多个内分泌器官增生，表现为异位促肾上腺皮质激素（ACTH）综合征、类癌综合征和巨人症。肿瘤细胞组织化学嗜银反应呈阳性，通过电子显微镜鉴定出两种分泌颗粒。生化分析显示肿瘤细胞可产生ACTH和β-促黑素（β-MSH）。多个内分泌器官的其他变化包括垂体嗜酸性细胞为主的增生、甲状腺弥漫性增生、甲状旁腺主细胞增生、胰岛增生以及肾上腺皮质增生。该病例被认为是一种包括类癌肿瘤的多发性内分泌腺瘤病。文中讨论了类癌肿瘤与多发性内分泌腺瘤病之间的关系。
