Matsuyama M, Inoue T, Ariyoshi Y, Doi M, Suchi T, Sato T, Tashiro K, Chihara T
Cancer. 1979 Nov;44(5):1813-23. doi: 10.1002/1097-0142(197911)44:5<1813::aid-cncr2820440541>3.0.co;2-q.
The case of a 38-year-old female with primary argyrophil cell carcinoma of the uterine cervix is reported. Two years after operation the patient developed widespread metastases with typical Cushing's syndrome. Microscopically, the tumor consisted of solid anaplastic cells, adenocarcinoma, and squamous cells. The plasma levels of ACTH and cortisol were elevated. Many cells of both the primary and metastatic tumors showed argyrophilia. Almost all the cells of the metastases contained numerous round secretory granules measuring about 117 micrometers in diameter. Small rod-shaped or larger round secretory granules, measuring 250 and 430 micrometers respectively, were also found in a few of these cells. The tumors in the right lung, pancreas, and kidney contained high levels of ACTH, beta-MSH, serotonin, histamine, and amylase. This is the first report of ectopic production of these five substances from argyrophil cell carcinoma of the uterine cervix.
报告了一例38岁患有原发性子宫颈嗜银细胞癌的女性病例。术后两年，患者出现广泛转移并伴有典型的库欣综合征。显微镜下，肿瘤由实性间变细胞、腺癌和鳞状细胞组成。促肾上腺皮质激素（ACTH）和皮质醇的血浆水平升高。原发性肿瘤和转移性肿瘤的许多细胞均显示嗜银性。转移灶的几乎所有细胞都含有大量直径约117微米的圆形分泌颗粒。在其中一些细胞中还发现了分别为250微米和430微米的小杆状或更大的圆形分泌颗粒。右肺、胰腺和肾脏中的肿瘤含有高水平的ACTH、β-促黑素（β-MSH）、血清素、组胺和淀粉酶。这是子宫颈嗜银细胞癌异位产生这五种物质的首例报告。
