Hoffman Allison C, Simmons Dee
Center for Tobacco Products, Food and Drug Administration, Rockville, MD 20850, USA.
Tob Induc Dis. 2011 May 23;9 Suppl 1(Suppl 1):S5. doi: 10.1186/1617-9625-9-S1-S5.
Since tobacco use is driven by dependence on nicotine, the primary addictive substance in tobacco, much research has focused on nicotine dependence. Less well understood, however, is the role that menthol plays in nicotine dependence. This review seeks to examine what role, if any, menthol plays in nicotine addiction in adults and youth. Based on research examining several indicators of heaviness of nicotine addiction, including time to first cigarette upon waking, night waking to smoke, as well as some other indications of dependence, it is suggested that menthol cigarette smokers are more heavily dependent on nicotine. Although other indicators of nicotine dependence, including number of cigarettes per day and the Fagerstrom Test of Nicotine Dependence, failed to consistently differentiate menthol and non-menthol smokers, these indicators are thought to be less robust than time to first cigarette. Therefore, though limited, the existing literature suggests that menthol smokers may be more dependence on nicotine.
由于烟草使用是由对尼古丁（烟草中的主要成瘾物质）的依赖所驱动的，许多研究都集中在尼古丁依赖上。然而，人们对薄荷醇在尼古丁依赖中所起的作用了解较少。这篇综述旨在探讨薄荷醇在成人和青少年尼古丁成瘾中是否发挥作用以及发挥何种作用。基于对尼古丁成瘾严重程度的几个指标的研究，包括醒来后第一支烟的时间、夜间醒来吸烟以及其他一些依赖指标，研究表明吸薄荷醇香烟的人对尼古丁的依赖程度更高。尽管尼古丁依赖的其他指标，包括每天吸烟数量和尼古丁依赖的法格斯特龙测试，未能持续区分吸薄荷醇香烟者和不吸薄荷醇香烟者，但这些指标被认为不如醒来后第一支烟的时间可靠。因此，尽管现有文献有限，但表明吸薄荷醇香烟者可能对尼古丁的依赖性更强。
