Altria Client Services Inc., Center for Research and Technology, 601 E. Jackson Street, Richmond, VA 23219, USA.
Regul Toxicol Pharmacol. 2010 Jun;57(1):24-30. doi: 10.1016/j.yrtph.2009.12.003. Epub 2009 Dec 16.
There is limited information comparing biomarkers of exposure (BOE) to cigarette smoke in menthol (MS) and non-menthol cigarette smokers (NMS).
To compare BOE to nicotine and carbon monoxide in MS and NMS.
Cross-sectional, observational, ambulatory, multi-centre study in 3341 adult cigarette smokers. Nicotine equivalents (NE) in 24h urine, NE/cigarette, COHb and serum cotinine were measured. Statistical analyses included analysis of variance and Wilcoxon test.
Analyses of variance revealed no statistically significant effects of mentholated cigarettes on NE/24h, COHb, serum cotinine and NE/cigarette. On average MS smoked 15.0 and NMS 16.8 cigarettes/day. The unadjusted mean differences were as follows: MS had lower NE/24h (5.4%) and COHb (3.2%), higher serum cotinine (3.0%) and NE/cigarette (5.7%) than NMS. African-Americans MS smoked 40% fewer cigarettes, showed lower NE/24h (24%) and COHb (10%) and higher NE/cig (29%) and serum cotinine (8%) levels than their White counterparts.
Smoking mentholated cigarettes does not increase daily exposure to smoke constituents as measured by NE and COHb. These findings are consistent with the majority of epidemiological studies indicating no difference in smoking related risks between MS and NMS.
有关比较薄荷醇（MS）和非薄荷醇香烟吸烟者暴露生物标志物（BOE）与香烟烟雾中生物标志物的信息有限。
比较 MS 和 NMS 吸烟者的 BOE 与尼古丁和一氧化碳。
横断面、观察性、门诊、多中心研究，纳入 3341 名成年香烟吸烟者。测量 24 小时尿液中的尼古丁当量（NE）、每支香烟的 NE、COHb 和血清可替宁。统计分析包括方差分析和 Wilcoxon 检验。
方差分析显示薄荷醇香烟对 NE/24h、COHb、血清可替宁和 NE/支没有统计学显著影响。MS 平均每天吸烟 15.0 支，NMS 平均每天吸烟 16.8 支。未经调整的平均差异如下：MS 的 NE/24h（5.4%）和 COHb（3.2%）较低，血清可替宁（3.0%）和 NE/支（5.7%）较高。非裔美国人 MS 吸烟量减少了 40%，NE/24h（24%）和 COHb（10%）较低，NE/支（29%）和血清可替宁（8%）水平较高，与他们的白人同龄人相比。
吸薄荷醇香烟不会增加每日对烟雾成分的暴露，如 NE 和 COHb 测量所示。这些发现与大多数流行病学研究一致，表明 MS 和 NMS 之间的吸烟相关风险没有差异。
