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中风后抑郁症中的α-2肾上腺素能受体功能

Alpha-2 adrenergic receptor function in post-stroke depression.

作者信息

Barry S, Dinan T G

机构信息

Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Ireland.

出版信息

Psychol Med. 1990 May;20(2):305-9. doi: 10.1017/s003329170001761x.

DOI:10.1017/s003329170001761x
PMID:2162547
Abstract

The growth hormone (GH) response to desipramine was measured in ten patients meeting criteria for post-stroke depression (PSD), eight age-matched post-stroke (PS) non-depressed patients and eight healthy controls. Responses were significantly blunted in patients with PSD. These findings suggest diminished alpha-2 adrenoceptor function may be an important marker for PSD.

摘要

对10名符合中风后抑郁症（PSD）标准的患者、8名年龄匹配的中风后（PS）非抑郁症患者和8名健康对照者测量了去郁敏对生长激素（GH）的反应。PSD患者的反应明显减弱。这些发现表明，α-2肾上腺素能受体功能减退可能是PSD的一个重要标志。

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