Bryer J B, Starkstein S E, Votypka V, Parikh R M, Price T R, Robinson R G
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
J Neuropsychiatry Clin Neurosci. 1992 Fall;4(4):440-2. doi: 10.1176/jnp.4.4.440.
Monoamine metabolites were measured in the cerebrospinal fluid (CSF) of depressed and nondepressed patients with acute stroke lesions and in nondepressed patients without stroke lesions. Depressed stroke patients had a significantly lower concentration of CSF 5-hydroxyindoleacetic acid (5-HIAA; a serotonin metabolite) than the other two groups. These findings suggest that poststroke depression may be mediated by serotonergic mechanisms.
在患有急性中风损伤的抑郁和非抑郁患者以及无中风损伤的非抑郁患者的脑脊液（CSF）中测量单胺代谢产物。抑郁的中风患者脑脊液中5-羟吲哚乙酸（5-HIAA，一种血清素代谢产物）的浓度明显低于其他两组。这些发现表明，中风后抑郁可能由血清素能机制介导。
