Mehta Suneela, Wells Sue, Riddell Tania, Kerr Andrew, Pylypchuk Romana, Marshall Roger, Ameratunga Shanthi, Chan Wing Cheuk, Thornley Simon, Crengle Sue, Harrison Jeff, Drury Paul, Elley C Raina, Bell Fionna, Jackson Rod
Section of Epidemiology and Biostatistics, School of Population Health, The University of Auckland, PB 92019 Auckland, New Zealand.
J Prim Health Care. 2011 Jun 1;3(2):93-101.
Blood pressure-lowering (BPL) and lipid-lowering (LL) medications together reduce estimated absolute five-year cardiovascular disease (CVD) risk by >40%. International studies indicate that the proportion of people with CVD receiving pharmacotherapy increases with advancing age.
To compare BPL and LL medications, by sociodemographic characteristics, for patients with known CVD in primary care settings.
The study population included patients aged 35-74 with known CVD assessed in primary care from July 2006 to October 2009 using a web-based computerised decision support system (PREDICT) for risk assessment and management. Clinical data linked anonymously to national sociodemographic and pharmaceutical dispensing databases. Differences in dispensing BPL and LL medications in six months before first PREDICT assessment was analysed according to age, sex, ethnicity and deprivation.
Of 7622 people with CVD, 1625 <55 years old, 2862 were women and 4609 lived in deprived areas (NZDep quintiles 4/5). The study population included 4249 European, 1556 Maori, 1151 Pacific and 329 Indian peoples. BPL medications were dispensed to 81%, LL medications to 73%, both BPL and LL medications to 67%, and 87% received either class of medication. Compared with people aged 65-75, people aged 35-44 were 30-40% less likely and those aged 45-54 were 10-15% less likely to be dispensed BPL, LL medications or both. There were minimal differences in likelihood of dispensing according to sex, ethnicity or deprivation.
BPL and LL medications are under-utilised in patients with known CVD in New Zealand. Only two-thirds of patients in this cohort are on both. Younger patients are considerably less likely to be on recommended medications.
降压药(BPL)和降脂药(LL)联合使用可使估计的五年心血管疾病(CVD)绝对风险降低40%以上。国际研究表明,接受药物治疗的心血管疾病患者比例随年龄增长而增加。
在初级保健机构中,按社会人口学特征比较已知患有心血管疾病患者使用的降压药和降脂药。
研究人群包括2006年7月至2009年10月在初级保健机构中使用基于网络的计算机决策支持系统(PREDICT)进行风险评估和管理的35至74岁已知患有心血管疾病的患者。临床数据与国家社会人口学和药品配给数据库进行匿名关联。根据年龄、性别、种族和贫困程度分析首次PREDICT评估前六个月内开具降压药和降脂药的差异。
在7622名心血管疾病患者中,1625名年龄小于55岁,2862名是女性,4609名居住在贫困地区(新西兰贫困指数五分位数4/5)。研究人群包括4249名欧洲人、1556名毛利人、1151名太平洋岛民和329名印度人。81%的患者开具了降压药,73%的患者开具了降脂药,67%的患者同时开具了降压药和降脂药,87%的患者接受了其中一类药物。与65至75岁的人群相比,35至44岁的人群开具降压药、降脂药或两者的可能性要低30%至40%,45至54岁的人群则低10%至15%。根据性别、种族或贫困程度,开具药物的可能性差异极小。
在新西兰,已知患有心血管疾病的患者对降压药和降脂药的使用不足。该队列中只有三分之二的患者同时使用这两种药物。年轻患者使用推荐药物的可能性要低得多。