Orthopaedic Department, Oslo University Hospital and University of Oslo, Kirkevn 166, 0407 Oslo, Norway.
Osteoporos Int. 2012 Mar;23(3):901-5. doi: 10.1007/s00198-011-1628-8. Epub 2011 Apr 6.
We found no difference in the rate of radiological hip osteoarthritis in the injured hip when comparing 349 patients with proximal femoral fractures and 112 patients with hip contusion. There was, however, a tendency for more osteoarthritis in patients with trochanteric fractures than in patients with femoral neck fractures.
Osteoarthritis (OA) and osteoporotic fractures are two age-related disorders associated with considerable morbidity. There is a clinical impression of an inverse relation between osteoarthritis and osteoporosis, and a protective effect of OA against osteoporotic fractures has been proposed.
We performed a case-control study in 461 subjects. Cases (n = 349) were patients aged 50 years or above who sustained a proximal femoral fracture from November 2003 to October 2004, registered prospectively in the department's fracture register. Controls (n = 112) were patients aged 50 years or above with the diagnosis of hip contusion, recruited from the hospital's discharge register. Radiographic OA was scored according to Kellgren and Lawrence (K&L), and minimal joint space (MJS) was measured in both hips when possible. A K&L grade II or higher or an MJS less than 2.5 mm was defined as OA.
Both in the hip fracture group and in the contusion group mean, the MJS was 3.5 mm on the injured side (p = 0.79). In the fracture group, 31/250 (12%) had MJS <2.5 mm and 16/112 (14%) in the contusion group (p = 0.18). In the fracture group, 40/250 (16%) had a K&L OA grade II or higher, and in the contusion group 20/112 (18%) persons had a K&L OA grade II or higher (p = 0.66). There was a tendency for a higher incidence of OA in patients with trochanteric fractures compared with patients with cervical fractures.
We found no differences on the injured side in the rate of hip OA between hip fracture patients and hip contusion patients.
在比较 349 例股骨近端骨折患者和 112 例髋部挫伤患者时,我们发现受伤髋关节的放射学髋关节骨关节炎发生率没有差异。然而,转子间骨折患者的骨关节炎发生率高于股骨颈骨折患者。
骨关节炎(OA)和骨质疏松性骨折是两种与发病率高相关的与年龄相关的疾病。临床上有一种印象,认为 OA 和骨质疏松之间存在反比关系,并且提出 OA 对骨质疏松性骨折有保护作用。
我们对 461 名受试者进行了病例对照研究。病例(n=349)为 2003 年 11 月至 2004 年 10 月期间 50 岁以上因股骨近端骨折而登记的前瞻性部门骨折登记处的患者。对照组(n=112)为 50 岁以上因髋部挫伤而从医院出院登记处招募的患者。根据 Kellgren 和 Lawrence(K&L)评分对放射学 OA 进行评分,并尽可能测量双侧髋关节的最小关节间隙(MJS)。K&L 分级 II 级或更高或 MJS 小于 2.5mm 定义为 OA。
在髋部骨折组和髋部挫伤组中,受伤侧的平均 MJS 均为 3.5mm(p=0.79)。在骨折组中,250 例中有 31 例(12%)MJS<2.5mm,112 例中有 16 例(14%)(p=0.18)。在骨折组中,250 例中有 40 例(16%)K&L 分级 II 级或更高,而在挫伤组中,112 例中有 20 例(18%)(p=0.66)。转子间骨折患者的 OA 发生率高于股骨颈骨折患者。
我们发现髋部骨折患者和髋部挫伤患者受伤侧髋关节骨关节炎发生率无差异。