College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Biol Trace Elem Res. 2011 Dec;144(1-3):1032-8. doi: 10.1007/s12011-011-9088-8. Epub 2011 May 28.
To investigate the effects of aluminum (Al) exposure on peritoneal macrophages of Wistar rats, four groups of ten rats each were orally exposed to 0, 13, 26, and 52 mg kg(-1) Al(3+) in form of aluminum trichloride (AlCl(3)) in drinking water for 120 days. At the end of the experimental period, the Al concentration in serum, the adherence, chemotaxis, and phagocytosis capacity of peritoneal macrophages were determined. The results showed that the Al concentration in serum significantly increased in a dose-dependent manner; the adherence, chemotaxis, and phagocytosis capacity of peritoneal macrophages decreased with the increase of Al dose, and present a dose-effective relationship. Further, they were significantly lower in the high-dose groups (P < 0.01) compared with the control group. It indicates that Al was toxic to peritoneal macrophages of rats, and the adherence, chemotaxis, and phagocytosis capacity of peritoneal macrophages in rats were significantly suppressed by exposure to 52 mg kg(-1) day Al(3+).
为了研究铝（Al）暴露对 Wistar 大鼠腹腔巨噬细胞的影响，将四组各 10 只大鼠分别经口给予三氯化铝（AlCl3）形式的 0、13、26 和 52 mg kg-1 Al（3+），连续染毒 120 天。实验期末，检测血清中 Al 浓度、腹腔巨噬细胞的黏附、趋化和吞噬能力。结果表明，血清中 Al 浓度呈剂量依赖性显著增加；腹腔巨噬细胞的黏附、趋化和吞噬能力随 Al 剂量的增加而降低，呈剂量-效应关系。而且，与对照组相比，高剂量组显著降低（P < 0.01）。表明 Al 对大鼠腹腔巨噬细胞具有毒性，大鼠腹腔巨噬细胞的黏附、趋化和吞噬能力被 52 mg kg-1 day Al（3+）暴露显著抑制。
