Division of Endocrinology, Department of Medicine, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Sleep Breath. 2012 Mar;16(1):163-8. doi: 10.1007/s11325-010-0468-7. Epub 2011 May 29.
The study aims to assess the risk factors for the presence and severity of obstructive sleep apnea (OSA) among severely obese patients evaluated for bariatric surgery.
Polysomnography recordings were performed in consecutive patients undergoing Roux-en-Y gastric bypass from January 2004 to January 2007. Sleep apnea was noted as present or absent and graded from mild to severe according to the apnea/hypopnea index. Patient gender, age, weight, height, body mass index, neck circumference, and waist circumference were recorded.
A total of 132 patients were included in the study group, and 85 patients had a confirmed diagnosis of OSA (64.4%). The prevalence of OSA was 55.7% in female and 77.4% in male. The prevalence of moderate or severe sleep apnea was higher in males (71.6%) than in females (31.6%). In OSA patients, body mass index (p = 0.020), neck circumference (p < 0.001), and age (p = 0.003) were higher as compared with obese patients without OSA, whereas no differences were found in waist circumference between groups. After multiple regression analysis, body mass index, age, and male gender were independent predictors of sleep apnea. In the female group, age greater than 49 years was the only significant predictor of moderate or severe OSA (odds ratio 5.42 (95% confidence interval 1.61-18.1); p = 0.006).
Males and females with age greater than 49 years are at greatest risk for OSA. Preoperative sleep studies should be mandatory in this group of severely obese patients.
本研究旨在评估接受减重手术评估的重度肥胖患者中阻塞性睡眠呼吸暂停(OSA)存在和严重程度的危险因素。
对 2004 年 1 月至 2007 年 1 月连续接受 Roux-en-Y 胃旁路术的患者进行多导睡眠图记录。根据呼吸暂停/低通气指数,将睡眠呼吸暂停分为存在或不存在,并分为轻度至重度。记录患者的性别、年龄、体重、身高、体重指数、颈围和腰围。
共有 132 例患者纳入研究组,其中 85 例患者确诊为 OSA(64.4%)。女性 OSA 的患病率为 55.7%,男性为 77.4%。男性中度或重度睡眠呼吸暂停的患病率(71.6%)高于女性(31.6%)。在 OSA 患者中,体重指数(p=0.020)、颈围(p<0.001)和年龄(p=0.003)均高于无 OSA 的肥胖患者,而两组间腰围无差异。多元回归分析后,体重指数、年龄和男性是睡眠呼吸暂停的独立预测因素。在女性组中,年龄大于 49 岁是中重度 OSA 的唯一显著预测因素(优势比 5.42(95%置信区间 1.61-18.1);p=0.006)。
年龄大于 49 岁的男性和女性患 OSA 的风险最大。对于这组重度肥胖患者,应强制进行术前睡眠研究。