Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
Surg Today. 2011 Jun;41(6):881-3. doi: 10.1007/s00595-010-4344-7. Epub 2011 May 28.
Hepatocellular adenoma is a rare, benign neoplasm that is related to the use of contraceptives or androgenic-anabolic steroids. A 51-year-old man with no history of steroid use was found to have a liver tumor. Plain computed tomography showed a high-density tumor that was enhanced in the arterial phase, and the enhancement was prolonged in the delayed phase. Magnetic resonance imaging showed that the tumor was hyperintense on in- and opposed-phase T1-weighted gradient recalled echo images and hyperintense on T1-weighted spin echo images. A partial hepatic resection was performed. A histological examination revealed normal hepatocyte-like tumor cells, composed of abundant dark brown granules of Dubin-Johnson-like pigment, which stained positively for Masson-Fontana stain. The tumor was diagnosed to be a very rare hepatocellular adenoma with the deposition of Dubin-Johnson-like pigment.
肝细胞腺瘤是一种罕见的良性肿瘤,与使用避孕药或雄激素-合成代谢类固醇有关。一名 51 岁、无类固醇使用史的男性被发现患有肝肿瘤。腹部 CT 平扫显示高密度肿瘤,动脉期强化,延迟期强化延长。磁共振成像显示肿瘤在同反相位 T1 加权梯度回波图像上呈高信号,在 T1 加权自旋回波图像上呈高信号。行部分肝切除术。组织学检查显示正常的肝细胞样肿瘤细胞,由丰富的棕褐色 Dubin-Johnson 样色素颗粒组成,Masson-Fontana 染色阳性。诊断为非常罕见的肝细胞腺瘤伴 Dubin-Johnson 样色素沉积。