Yamamoto Tomohiro, Honda Hiroyuki, Kohno Tatsuro
Division of Anesthesiology, Niigata University Graduate School of Medicine and Dental Sciences, Niigata 951-8510.
Masui. 2011 May;60(5):582-9.
The essential elements of anesthesia are : hypnosis, amnesia, analgesia, immobility, and inhibition of untoward reflexes. The spinal cord is responsible for the latter three. Suppression of excitatory transmission and stimulation of inhibitory transmission are the anesthetic mechanisms in the spinal cord. Each anesthetic, however, has a unique effect on the transmission systems in the spinal cord. Some exclusively suppress excitatory transmission or stimulate inhibitory transmission, and others have a dual effect. The minimum alveolar/anesthetic concentration (MAC) is spinally mediated. Furthermore neurons in the ventral horn of spinal cord seem to be more depressed by anesthetics than neurons in the dorsal horn of the spinal cord. The ventral spinal cord also has relation to spinal cord ischemia. Investigation of the neuroprotective effect against spinal ischemia as well as the anesthetic effect in the ventral spinal cord is a very important subject of research.
催眠、失忆、镇痛、肌肉松弛及抑制不良反射。脊髓负责后三项功能。抑制兴奋性传递和刺激抑制性传递是脊髓中的麻醉机制。然而，每种麻醉药对脊髓中的传递系统都有独特的作用。有些麻醉药专门抑制兴奋性传递或刺激抑制性传递，而其他一些则具有双重作用。最低肺泡/麻醉浓度（MAC）由脊髓介导。此外，脊髓腹角的神经元似乎比脊髓背角的神经元更容易受到麻醉药的抑制。脊髓腹侧也与脊髓缺血有关。研究针对脊髓缺血的神经保护作用以及脊髓腹侧的麻醉效果是一个非常重要的研究课题。
