Bjøro T, Sand O, Ostberg B C, Gordeladze J O, Torjesen P, Gautvik K M, Haug E
Hormone Laboratory, Aker Hospital, Oslo, Norway.
Biosci Rep. 1990 Apr;10(2):189-99. doi: 10.1007/BF01116578.
The effect of vasoactive intestinal peptide (VIP) on prolactin (PRL) secretion from pituitary cells is reviewed and compared to the effect of thyrotropin releasing hormone (TRH). These two peptides induced different secretion profiles from parafused lactotrophs in culture. TRH was found to increase PRL secretion within 4 s and induced a biphasic secretion pattern, while VIP induced a monophasic secretion pattern after a lag time of 45-60 s. The secretion profiles are compared to changes in adenylate cyclase activity, production of inositol polyphosphates, changes in intracellular calcium concentrations and changes in electrophysiological properties of the cell membrane.
综述了血管活性肠肽（VIP）对垂体细胞催乳素（PRL）分泌的影响，并与促甲状腺激素释放激素（TRH）的作用进行了比较。这两种肽在培养的灌流乳促素细胞中诱导出不同的分泌模式。发现TRH在4秒内增加PRL分泌，并诱导双相分泌模式，而VIP在45 - 60秒的延迟时间后诱导单相分泌模式。将这些分泌模式与腺苷酸环化酶活性的变化、肌醇多磷酸的产生、细胞内钙浓度的变化以及细胞膜电生理特性的变化进行了比较。
