Ambroise Moses, Ghosh Mitra, Mallikarjuna V S, Kurian Ann
Department of Histopathology, Apollo Speciality Hospital, Chennai, India.
Asian Pac J Cancer Prev. 2011;12(3):625-9.
This is a retrospective study of 321 female invasive breast carcinomas diagnosed in the Department of Histopathology, Apollo Speciality Hospital, Chennai from January 2009 to June 2010.
The age of the patients ranged from 24 to 99 years, with a mean of 53.8, and the majority of the tumors were T2 (83.8% in range of 2-5 cms), predominantly histological grade 2 (57.3%), followed by grade 3 (33.3%). ER, PR and Her-2/neu expression was seen in 59, 51 and 27% of cases respectively. Triple-negative breast cancers constituted 25 % of our cases. We also found characteristic associations between hormonal receptor and Her-2/neu expression and various clinico-pathological parameters.
The hormonal receptor expression appears to be lower in the Indian population compared to the West. A significant proportion of tumors in our study with Her2/neu overexpression also showed ER and PR positivity. Triple-negative breast tumors were most commonly grade 3, in women aged more than 50 years.
1）通过免疫组织化学评估浸润性乳腺癌中雌激素受体（ER）、孕激素受体（PR）和Her-2/neu的表达；2）比较其表达模式与临床病理参数，如患者年龄、肿瘤大小、有丝分裂指数、组织学类型和分级以及淋巴结转移情况。
这是一项对2009年1月至2010年6月在金奈阿波罗专科医院组织病理学部门诊断的321例女性浸润性乳腺癌的回顾性研究。
患者年龄在24至99岁之间，平均年龄为53.8岁，大多数肿瘤为T2期（2至5厘米范围内占83.8%），主要组织学分级为2级（57.3%），其次是3级（33.3%）。ER、PR和Her-2/neu表达分别见于59%、51%和27%的病例。三阴性乳腺癌占我们病例的25%。我们还发现激素受体与Her-2/neu表达以及各种临床病理参数之间存在特征性关联。
与西方相比，印度人群中激素受体表达似乎较低。在我们的研究中，相当一部分Her2/neu过表达的肿瘤也显示ER和PR阳性。三阴性乳腺肿瘤最常见于50岁以上女性，多为3级。
