State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, People's Republic of China.
Can J Microbiol. 2011 Jun;57(6):468-75. doi: 10.1139/w11-028. Epub 2011 May 31.
A regulatory circuit composed of three porins (OmpF, OmpC, and OmpX) and two transcriptional regulators (OmpR and CRP) has previously been characterized in Yersinia pestis . In this follow-up study, OmpF2, an OmpF paralogue, was integrated into this regulatory circuit. Only basal expression was detected for ompF2 in the wild-type strain under different osmotic conditions. The ompF2 transcription was dramatically enhanced with increasing medium osmolarity in the ompR null mutant background. The CRP regulator had no regulatory effect on ompF2 under the growth conditions tested.
先前在鼠疫耶尔森氏菌中已鉴定出由三种孔蛋白（OmpF、OmpC 和 OmpX）和两个转录调节因子（OmpR 和 CRP）组成的调控回路。在这项后续研究中，将 OmpF 旁系同源物 OmpF2 整合到该调控回路中。在不同的渗透条件下，野生型菌株中仅检测到基础水平的 ompF2 表达。在 ompR 缺失突变体背景下，随着培养基渗透压的增加，ompF2 的转录显著增强。在测试的生长条件下，CRP 调节因子对 ompF2 没有调节作用。
