Nielsen Simon Uhl, Jansen Tejs, Johansen Sys Stybe, Linnet Kristian, Gregersen Peter, Høgberg Lotte Christine Groth
Anæstesiafdelingen, Bispebjerg Hospital, Denmark.
Ugeskr Laeger. 2011 May 30;173(22):1578-9.
Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.
一名年轻男子曾两次因故意过量服用巴氯芬而入院。第一次摄入剂量为1850毫克，第二次高达2500毫克。在这两起病例中，患者均出现严重的过量症状，格拉斯哥昏迷量表评分为4 - 5分，并被收入重症监护病房。随即启动了连续性静脉-静脉血液透析滤过（CVVHDF）。巴氯芬的消除药代动力学和毒代动力学尚未完全明确。在第二次就诊时观察到消除半衰期较短，这可能是由于巴氯芬的房室分布，或者更有可能是由CVVHDF的有利作用所致。
