Sein Anand Jacek, Chodorowski Zygmunt, Burda Piotr
1st Clinic of Internal Diseases and Acute Poisonings, Medical University of Gdańsk, Poland.
Przegl Lek. 2005;62(6):462-4.
Baclofen is a lipophilic analogue of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in central nervous system. The aim of the study was to evaluate some clinical aspects of acute intoxication with baclofen. Fifty two patients (37 females and 15 males) aged from 14 to 58 (mean 30.6 +/- 13.7) years were analyzed. Patients were admitted to the Clinic of Internal Diseases and Acute Poisonings Medical University of Gdańsk and the Centre of Acute Poisonings of Praski Hospital in Warszawa during the years 1996-2004 because of suicidal intoxication with baclofen. The doses of baclofen varied from 100 to 1500 (mean 444.8 +/- 317.8) mg. There were twenty eight patients (53.8%) in deep coma (III and IV grade of Matthew scale). Acute respiratory failure which required mechanical ventilation was observed in 18 cases (34.6%). Cardiac abnormalities included bradycardia (36.5%), hypertension (32.7%) and hypotension (3.8%). Toxic psychoses were observed in 6 cases (11.5%). The dosage of baclofen in patients with acute respiratory failure (ARF) was significantly higher than in patients without ARF. Treatment of patients with acute baclofen intoxication should take place in hospitals appropriately equipped which can provide artificial respiration.
巴氯芬是γ-氨基丁酸（GABA，中枢神经系统中的一种抑制性神经递质）的亲脂性类似物。本研究的目的是评估巴氯芬急性中毒的一些临床情况。分析了52例年龄在14至58岁（平均30.6±13.7岁）的患者（37名女性和15名男性）。这些患者在1996年至2004年期间因巴氯芬自杀性中毒而入住格但斯克医科大学内科与急性中毒诊所及华沙普拉斯基医院急性中毒中心。巴氯芬的剂量从100至1500毫克（平均444.8±317.8毫克）不等。有28例患者（53.8%）处于深度昏迷（马修量表III级和IV级）。18例患者（34.6%）观察到需要机械通气的急性呼吸衰竭。心脏异常包括心动过缓（36.5%）、高血压（32.7%）和低血压（3.8%）。6例患者（11.5%）观察到中毒性精神病。急性呼吸衰竭（ARF）患者的巴氯芬剂量显著高于无ARF的患者。急性巴氯芬中毒患者的治疗应在配备适当、能够提供人工呼吸的医院进行。
