Institute for Molecular Cell Biology, Medical Faculty, Saarland University, Homburg/Saar, Germany.
Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7):a004556. doi: 10.1101/cshperspect.a004556.
The coordinated and physiological behavior of living cells in an organism critically depends on their ability to interact with surrounding cells and with the extracellular space. For this, cells have to interpret incoming stimuli, correctly process the signals, and produce meaningful responses. A major part of such signaling mechanisms is the translation of incoming stimuli into intracellularly understandable signals, usually represented by second messengers or second-messenger systems. Two key second messengers, namely the calcium ion and signaling lipids, albeit extremely different in nature, play an important and often synergistic role in such signaling cascades. In this report, we will shed some light on an entire family of protein kinases, the protein kinases C, that are perfectly designed to exactly decode these two second messengers in all of their properties and convey the signaling content to downstream processes within the cell.
生物体中活细胞的协调和生理行为严重依赖于它们与周围细胞和细胞外空间相互作用的能力。为此，细胞必须解释传入的刺激，正确处理信号，并产生有意义的反应。这种信号机制的一个主要部分是将传入的刺激转化为细胞内可理解的信号，通常由第二信使或第二信使系统表示。两种主要的第二信使，即钙离子和信号脂质，尽管在性质上截然不同，但在这种信号级联中起着重要的、往往是协同的作用。在本报告中，我们将介绍一组蛋白激酶，即蛋白激酶 C，它们是专门设计来精确解码这两种第二信使的所有特性，并将信号内容传递到细胞内的下游过程。
