Martin C G, Hansen T N, Goddard-Finegold J, LeBlanc A, Giesler M E, Smith S
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
J Clin Ultrasound. 1990 Jul-Aug;18(6):487-95. doi: 10.1002/jcu.1870180606.
The purpose of this study was to evaluate the ability of pulsed Doppler ultrasonography to predict brain blood flow by comparing measurements made in basal cerebral arteries using a pulsed Doppler system with measurements of brain blood flow using radioactive microspheres in lambs. We measured the instantaneous maximum velocity during peak systole and end diastole and the mean velocity over the pulse cycle in basal cerebral arteries, calculated Pourcelot's index of resistance and Gosling's pulsatility index, and used regression analysis to compare the pulsed Doppler measurements with brain blood flow measured with radioactive microspheres. Pulsed Doppler measurements of the peak systolic, end diastolic, and mean flow velocity in basal cerebral arteries were directly related to brain blood flow. In contrast, no linear relationship was detected between the resistance or pulsatility indices and brain blood flow measured by microspheres (p greater than 0.14). Prediction of brain blood flow for individual subjects lacks the quantitative precision necessary for use as a clinical tool. However, the direct relationship between brain blood flow and the peak systolic, end diastolic, and mean flow velocities in basal cerebral arteries supports the use of these measurements in clinical research for the qualitative assessment of change in brain blood flow.
本研究的目的是通过比较使用脉冲多普勒系统在羔羊大脑基底动脉中进行的测量与使用放射性微球测量的羔羊脑血流量，来评估脉冲多普勒超声预测脑血流量的能力。我们测量了大脑基底动脉在收缩期峰值和舒张期末期的瞬时最大速度以及脉冲周期内的平均速度，计算了泊肃叶阻力指数和戈斯林搏动指数，并使用回归分析将脉冲多普勒测量结果与用放射性微球测量的脑血流量进行比较。大脑基底动脉收缩期峰值、舒张期末期和平均血流速度的脉冲多普勒测量结果与脑血流量直接相关。相比之下，未检测到阻力指数或搏动指数与微球测量的脑血流量之间存在线性关系（p大于0.14）。对个体受试者脑血流量的预测缺乏作为临床工具所需的定量精度。然而，脑血流量与大脑基底动脉收缩期峰值、舒张期末期和平均血流速度之间的直接关系支持在临床研究中使用这些测量来定性评估脑血流量的变化。
