Hansen N B, Stonestreet B S, Rosenkrantz T S, Oh W
Pediatrics. 1983 Oct;72(4):526-31.
Continuous wave Doppler ultrasonography through the anterior fontanel has recently been used to assess changes in cerebral blood flow in human neonates. There has been controversy concerning whether measurements of Doppler blood flow velocity indeed correlate with brain blood flow. An in vivo correlation was performed between brain blood flow as measured by the microsphere method and Doppler flow velocity measurements of the cerebral arteries via an artificial fontanel in young piglets. The peak systolic velocity (r = .76, P less than .001), end diastolic velocity (r = .72, P less than .001) and area under the velocity curve (r = .86, P less than .001) all showed significant positive correlations with brain blood flow. The pulsatility index did not correlate with brain blood flow. Although continuous wave Doppler flow velocity measurements of the anterior cerebral artery cannot quantitatively assess cerebral blood flow, this methodology can be used to correlate changes in cerebral blood flow and provide a meaningful trend analysis following physiologic or pharmacologic perturbation of the cerebral circulation.
最近，通过前囟门进行的连续波多普勒超声检查已被用于评估人类新生儿脑血流的变化。关于多普勒血流速度测量是否确实与脑血流量相关一直存在争议。在幼小猪中，通过微球法测量的脑血流量与通过人工囟门对脑动脉进行的多普勒血流速度测量之间进行了体内相关性研究。收缩期峰值速度（r = 0.76，P < 0.001）、舒张末期速度（r = 0.72，P < 0.001）和速度曲线下面积（r = 0.86，P < 0.001）均与脑血流量呈显著正相关。搏动指数与脑血流量无关。尽管大脑前动脉的连续波多普勒血流速度测量不能定量评估脑血流量，但该方法可用于关联脑血流量的变化，并在脑循环受到生理或药物干扰后提供有意义的趋势分析。
