Dallolio Laura, Franchino Giuseppe, Pieri Giulia, Raineri Cristina, Fantini Maria Pia
Dipartimento di medicina e sanità pubblica, Alma Mater Studiorum, Università di Bologna, Italy.
Epidemiol Prev. 2011 Mar-Apr;35(2):125-30.
to compare trends in infant, neonatal and post-neonatal mortality in Italy from 1991 to 2005 both at the national level and among the three Italian large geographical macro-areas (North, Center, South-Islands).
observational study based on routine data.
the analysis was performed on the cohort of newborns (up to the first age of life) in Italy from 1991 to 2005.
infant, neonatal and post-neonatal mortality rate calculated for 3-year and 5-year periods, relative risks, attributable fraction.
during the study period infant mortality rates significantly decreased from 7.72 to 3.91 per 1,000 births, neonatal mortality rates from 5.87 to 2.84 per 1,000 births, and postneonatal mortality rates from 1.85 to 1.08. Despite these significant reductions, important disparities persist in different geographical areas within Italy. In particular, rates appears to be much higher in the southern regions of the country: during the period 2001-2005 the excess of mortality in the South comparing with the North was 37%. Since 1998, following a change in legislation, individual matching of Certificates of Delivery Care (CedAP) and Death Certificates during the first year of life, at a national level, is not possible.
during the period 1991-2005 Italy experienced significant infant mortality reduction, but important geographical disparities still remain. In order to investigate these disparities and the determinants of infant mortality in Italy, the lack of routine data could represent an important limit to conduct update epidemiologic studies.
比较1991年至2005年意大利全国以及意大利三个大地理区域（北部、中部、南部-岛屿）婴儿、新生儿及新生儿后期的死亡率趋势。
基于常规数据的观察性研究。
分析对象为1991年至2005年意大利新生儿队列（直至生命的第一年）。
计算3年和5年期间的婴儿、新生儿及新生儿后期死亡率、相对风险、归因分数。
在研究期间，婴儿死亡率从每1000例出生7.72例显著降至3.91例，新生儿死亡率从每1000例出生5.87例降至2.84例，新生儿后期死亡率从1.85例降至1.08例。尽管有这些显著下降，但意大利不同地理区域仍存在重要差异。特别是，该国南部地区的死亡率似乎高得多：在2001 - 2005年期间，南部与北部相比死亡率高出37%。自1998年以来，由于立法变更，在全国范围内无法对出生后第一年的分娩护理证书（CedAP）和死亡证书进行个体匹配。
在1991 - 2005年期间，意大利婴儿死亡率显著降低，但重要的地理差异仍然存在。为了调查这些差异以及意大利婴儿死亡率的决定因素，常规数据的缺乏可能是进行最新流行病学研究的一个重要限制。
