Ohmori Kenji
Department of Pharmacology, Yokohama College of Pharmacy, Totsuka-ku, Yokohama, Japan.
Yakugaku Zasshi. 2011;131(6):939-43. doi: 10.1248/yakushi.131.939.
For the purpose of the development of new drugs for incurable diseases, many students enter graduate school of pharmaceutical sciences every year. At first, I expect education to let it develop more and spread without forgetting this will. Recently, withdrawals from Japan of the research institutes of the foreign-affiliated pharmaceutical companies have occurred successively. It is pointed out that there is it for the study about the biomedical research that is the next step of fundamental researches having been weak. I expect the immediate construction of the cluster, which consists of pharmaceutical companies and graduate schools of pharmaceutical sciences. Time of ten several years and a cost of one hundred billion yen are necessary for the research and development of new drug. The success probability is low, besides. Many trials are accomplished to raise the success probability. The one is introduction of the project system. The best members are gathered from the fields such as medicinal chemistry, molecular biology, biochemistry, pharmacology, pharmacokinetics, pharmaceutics and toxicological sciences, etc. The project system is a system enforcing go or stop by own judgment, an authority and the responsibility of the purpose are given. It is necessary for the project leader to have great knowledge and the abilities to hold lively discussion. It is a researcher from graduate school of pharmaceutical sciences that is the most suited to be as a project leader. I expect to upbring education from the time when a leader is young.
为了开发针对不治之症的新药,每年都有许多学生进入药学研究生院。起初,我期望教育能让其在不忘此目标的情况下得到更多发展和传播。最近,外资制药公司的研究机构相继撤离日本。有人指出,作为基础研究下一步的生物医学研究方面的学习很薄弱。我期望立即构建由制药公司和药学研究生院组成的集群。新药研发需要十几年的时间和一千亿日元的成本。此外,成功概率很低。为了提高成功概率,进行了许多尝试。其中之一是引入项目体系。从药物化学、分子生物学、生物化学、药理学、药代动力学、药剂学和毒理学等领域召集最优秀的成员。项目体系是一种自行判断实施或停止的体系,赋予其目标的权力和责任。项目负责人必须具备丰富的知识和进行热烈讨论的能力。最适合担任项目负责人的是药学研究生院的研究人员。我期望从领导者年轻时就开始培养相关教育。