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Nat Rev Gastroenterol Hepatol. 2011 May 31;8(7):405-15. doi: 10.1038/nrgastro.2011.91.
Exocrine pancreatic disease is thought to be uncommon in clinical practice and usually secondary to excess alcohol intake. Although excess alcohol intake does account for many cases of exocrine pancreatic disease, other conditions are associated with exocrine pancreatic insufficiency and such dysfunction perhaps occurs more frequently than conventionally expected. A reliable, patient-friendly, cheap and easy to use test for exocrine pancreatic disease is yet to be established; however, in many countries the main (and often only available) method of assessment of exocrine pancreatic function is the fecal-elastase-1 test. This Review examines the role of fecal-elastase-1 testing in detecting exocrine pancreatic insufficiency in a number of gastrointestinal and nongastrointestinal conditions and determines the value of pancreatic enzyme supplementation in these settings.
外分泌胰腺疾病在临床实践中并不常见，通常继发于过量饮酒。尽管过量饮酒确实会导致许多外分泌胰腺疾病，但其他疾病也与外分泌胰腺功能不全有关，这种功能障碍的发生频率可能比人们通常预期的要高。目前还没有一种可靠、适合患者、廉价且易于使用的外分泌胰腺疾病检测方法；然而，在许多国家，评估外分泌胰腺功能的主要方法（通常也是唯一可用的方法）是粪便弹性蛋白酶-1 检测。本综述检查了粪便弹性蛋白酶-1 检测在外分泌胰腺功能不全的几种胃肠道和非胃肠道疾病中的作用，并确定了在这些情况下补充胰腺酶的价值。
