Czakó L, Takács T, Farkas G, Boda K, Lonovics J
I. Belgyógyászati Klinika, Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
Orv Hetil. 1999 Aug 22;140(34):1887-90.
The diagnostic value of the estimation of faecal elastase-1, the new noninvasive direct pancreatic function test was evaluated in a total of 35 patients. Twenty one patients were diagnosed with chronic pancreatitis and categorized according to grades of exocrine pancreatic insufficiency based on the Lundh test, 14 patients in the control group had gastrointestinal disorders. Faecal elastase 1 was measured by ELISA method. The sensitivity, specificity, positive and negative predictive value and diagnostic accuracy of elastase determination was 71.4%, 92.8%, 88.2%, 81.2% and 83.7%, respectively in chronic pancreatitis. In the severe exocrine pancreas insufficiency group (n = 14), the sensitivity was 85.7%, while in the group with mild insufficiency (n = 7) the sensitivity was only 42.8%. The determination of faecal elastase is useful in the diagnosis of severe exocrine pancreas insufficiency, but it is not sensitive enough in the mild form of the disease.
在总共35例患者中评估了新型非侵入性直接胰腺功能检测——粪便弹性蛋白酶-1测定的诊断价值。21例患者被诊断为慢性胰腺炎，并根据基于伦德试验的外分泌性胰腺功能不全分级进行分类，14例对照组患者患有胃肠道疾病。采用酶联免疫吸附测定法（ELISA法）检测粪便弹性蛋白酶1。在慢性胰腺炎中，弹性蛋白酶测定的敏感性、特异性、阳性和阴性预测值以及诊断准确性分别为71.4%、92.8%、88.2%、81.2%和83.7%。在严重外分泌性胰腺功能不全组（n = 14）中，敏感性为85.7%，而在轻度功能不全组（n = 7）中，敏感性仅为42.8%。粪便弹性蛋白酶测定对严重外分泌性胰腺功能不全的诊断有用，但在疾病的轻度形式中不够敏感。
