Department of Medicine, University of British Columbia, UBC James Hogg Research Centre, Providence Heart + Lung Institute, Room 166, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.
Curr Genomics. 2010 Dec;11(8):591-606. doi: 10.2174/138920210793360907.
Interleukin 1 receptor-like 1 (IL1RL1) is gaining in recognition due to its involvement in immune/inflammatory disorders. Well-designed animal studies have shown its critical role in experimental allergic inflammation and human in vitro studies have consistently demonstrated its up-regulation in several conditions such as asthma and rheumatoid arthritis. The ligand for IL1RL1 is IL33 which emerged as playing an important role in initiating eosinophilic inflammation and activating other immune cells resulting in an allergic phenotype.An IL1RL1 single nucleotide polymorphism (SNP) was among the most significant results of a genome-wide scan investigating eosinophil counts; in the same study, this SNP associated with asthma in 10 populations.The IL1RL1 gene resides in a region of high linkage disequilibrium containing interleukin 1 receptor genes as well as interleukin 18 receptor and accessory genes. This poses a challenge to researchers interested in deciphering genetic association signals in the region as all of the genes represent interesting candidates for asthma and allergic disease.The IL1RL1 gene and its resulting soluble and receptor proteins have emerged as key regulators of the inflammatory process implicated in a large variety of human pathologies We review the function and expression of the IL1RL1 gene. We also describe the role of IL1RL1 in asthma, allergy, cardiovascular disease, infections, liver disease and kidney disease.
白细胞介素 1 受体样 1（IL1RL1）因其参与免疫/炎症性疾病而受到越来越多的关注。精心设计的动物研究表明，它在实验性过敏炎症中具有关键作用，而人类体外研究也一致表明，在哮喘和类风湿关节炎等几种情况下其表达上调。IL1RL1 的配体是 IL33，它在引发嗜酸性粒细胞炎症和激活其他免疫细胞导致过敏表型方面发挥着重要作用。白细胞介素 1 受体样 1 单核苷酸多态性（SNP）是全基因组扫描研究嗜酸性粒细胞计数的最重要结果之一；在同一项研究中，该 SNP 与 10 个人群中的哮喘有关。IL1RL1 基因位于高连锁不平衡区域，包含白细胞介素 1 受体基因以及白细胞介素 18 受体和辅助基因。这给有兴趣解析该区域遗传关联信号的研究人员带来了挑战，因为所有基因都代表了哮喘和过敏疾病的有趣候选基因。IL1RL1 基因及其产生的可溶性和受体蛋白已成为涉及多种人类病理的炎症过程的关键调节剂。我们综述了 IL1RL1 基因的功能和表达。我们还描述了 IL1RL1 在哮喘、过敏、心血管疾病、感染、肝病和肾病中的作用。
