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在单个组织切片上进行高空间分辨率成像质谱和经典组织学分析。

High spatial resolution imaging mass spectrometry and classical histology on a single tissue section.

机构信息

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA.

出版信息

J Mass Spectrom. 2011 Jun;46(6):568-71. doi: 10.1002/jms.1926.

DOI:10.1002/jms.1926
PMID:21630385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3118566/
Abstract

The work presented in this report describes and demonstrates a protocol for protein imaging analysis of biological tissue using MALDI IMS where histological staining and MS analysis are performed on the same tissue section. Spatial image resolution is shown at 35 µm for sagittal sections of the cerebellum from rat brain.

摘要

本报告中介绍的工作描述并展示了一种使用 MALDI IMS 对生物组织进行蛋白质成像分析的方案，其中组织学染色和 MS 分析在同一组织切片上进行。空间图像分辨率显示为大鼠脑矢状切片的 35 µm。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/debe/3118566/edf95fb4eee9/nihms291393f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/debe/3118566/672c55ef4696/nihms291393f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/debe/3118566/edf95fb4eee9/nihms291393f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/debe/3118566/672c55ef4696/nihms291393f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/debe/3118566/edf95fb4eee9/nihms291393f2.jpg

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