Amgen, Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
Chem Res Toxicol. 2011 Aug 15;24(8):1163-8. doi: 10.1021/tx200121m. Epub 2011 Jun 10.
The new generation of DNA sequencing devices surpass their predecessors' outputs by many orders of magnitude, a quantitative increase with qualitative implications. Sequencing at this scale enables many advances in basic and medical research, ranging from identification of new medically relevant biological mechanisms to maturation of personalized therapies. Nevertheless, as the genomics era plainly demonstrated, massive amounts of DNA sequence information by itself cannot fully illuminate the mysteries of human physiology, including the problems that challenge predictive toxicologists.
新一代 DNA 测序设备的产出比前代设备高出几个数量级，这是一种具有定性影响的定量增长。在这个规模上进行测序，可以推动基础和医学研究的许多进展，从鉴定新的具有医学相关性的生物学机制到个性化治疗的成熟。然而，正如基因组学时代所清楚表明的那样，大量的 DNA 序列信息本身并不能完全揭示人类生理学的奥秘，包括那些挑战预测毒理学家的问题。
