Barnes P J
Department of Thoracic Medicine, National Heart & Lung Institute, London.
Recenti Prog Med. 1990 Mar;81(3):184-92.
Airway smooth muscle tone is influenced by many neurotransmitters, inflammatory mediators and drugs which interact direct or indirectly with specific surface receptors on smooth muscle cells. There have recently been important advances in our understanding of receptor mechanisms which may be relevant to understanding altered receptor function in airway inflammatory diseases. Neural control of airway tone is complex and several transmitters may be involved, including adrenoceptors, muscarinic receptors and receptors for various neuropeptides. Several inflammatory mediators, acting via specific receptors, may also influence airway smooth muscle. In the future molecular techniques which give information about the factors influencing receptor synthesis and post-translation processing will also provide further insights into understanding receptor function in airway disease.
气道平滑肌张力受多种神经递质、炎症介质和药物影响，这些物质直接或间接与平滑肌细胞上的特定表面受体相互作用。最近，我们对受体机制的理解取得了重要进展，这可能与理解气道炎症性疾病中受体功能改变有关。气道张力的神经控制很复杂，可能涉及多种递质，包括肾上腺素能受体、毒蕈碱受体和各种神经肽的受体。几种炎症介质通过特定受体起作用，也可能影响气道平滑肌。未来，能够提供有关影响受体合成和翻译后加工因素信息的分子技术，也将为深入理解气道疾病中的受体功能提供更多见解。
