Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Arch Pathol Lab Med. 2011 Jun;135(6):766-9. doi: 10.5858/2010-0377-OA.1.
Recently we have observed distinctive acidophilic intranuclear inclusions in cases of usual intraductal hyperplasia of the breast. Similar inclusions were described almost 20 years ago in cases of mammary hyperplasia. These correlated ultrastructurally with so-called helioid inclusions. However, there since has been little discussion of these inclusions in the literature.
To examine the incidence and specificity of these inclusions in proliferative lesions of the breast.
Forty cases of usual intraductal hyperplasia, 15 cases of atypical ductal hyperplasia, and 34 cases of low-grade ductal carcinoma in situ were examined for the presence of acidophilic intranuclear inclusions.
Acidophilic intranuclear inclusions were present in 50% of cases of usual intraductal hyperplasia (20 of 40) but were not identified in any cases of atypical ductal hyperplasia (0 of 15) or low-grade ductal carcinoma in situ (0 of 34).
Acidophilic intranuclear inclusions appear to be a common, specific feature found in usual intraductal hyperplasia and may be helpful in distinguishing it from atypical ductal hyperplasia and low-grade ductal carcinoma in situ in some cases. Elucidating the nature of these inclusions may provide insight into the pathogenesis of usual intraductal hyperplasia.
最近，我们在乳腺普通导管增生病例中观察到具有特征性的嗜酸性核内包涵体。大约 20 年前，在乳腺增生病例中也描述了类似的包涵体。这些包涵体在超微结构上与所谓的“螺旋体包涵体”相关。然而，此后文献中对这些包涵体的讨论甚少。
研究这些包涵体在乳腺增生性病变中的发生率和特异性。
检查了 40 例普通导管增生、15 例非典型导管增生和 34 例低级别导管原位癌病例中是否存在嗜酸性核内包涵体。
嗜酸性核内包涵体在 50%的普通导管增生病例中存在（40 例中有 20 例），但在任何非典型导管增生病例（15 例中均无）或低级别导管原位癌病例（34 例中均无）中均未发现。
嗜酸性核内包涵体似乎是普通导管增生的一个常见且特异的特征，在某些情况下，它可能有助于将其与非典型导管增生和低级别导管原位癌区分开来。阐明这些包涵体的性质可能有助于了解普通导管增生的发病机制。
