Pedersen H, Neergaard K, Howitz P
Rigshospitalet, neuroradiologisk afsnit, København.
Ugeskr Laeger. 1990 May 28;152(22):1593-5.
A prospective investigation of 52 children with infantile spasms was carried out employing computed tomography. Normal conditions were demonstrated in 21 (40%). Among the 31 children with pathological computed tomografic findings, dilatation of the ventricular system and/or subarachnoid space was found in nine cases (17%), congenital malformations in ten (19%) and cerebrovascular changes in a similar number (19%). One patient had a tumour and one had congenital toxoplasmosis. No significant differences were found in the frequencies of normal psychomotor development between children with normal and abnormal computed tomographic findings. The reason for this is probably that a good prognosis may be anticipated in the idiopathic forms provided that ACTH treatment is initiated early in the course of the disease. Computed tomography is useful to differentiate between symptomatic and idiopathic cases of infantile spasms. It may, however, be assumed that neuronal heterotopy without other malformations in the central nervous system may be difficult to diagnose with computed tomography. Magnetic resonance scanning will probably be able to demonstrate these cases.
对52例婴儿痉挛症患儿进行了前瞻性计算机断层扫描研究。21例（40%）显示正常情况。在31例计算机断层扫描有病理表现的患儿中，9例（17%）发现脑室系统和/或蛛网膜下腔扩张，10例（19%）有先天性畸形，类似数量（19%）有脑血管改变。1例患儿有肿瘤，1例有先天性弓形虫病。计算机断层扫描结果正常和异常的患儿在正常精神运动发育频率方面未发现显著差异。原因可能是，对于特发性形式的婴儿痉挛症，只要在疾病早期开始促肾上腺皮质激素治疗，就可能预期有良好的预后。计算机断层扫描有助于区分婴儿痉挛症的症状性和特发性病例。然而，可以设想，中枢神经系统中无其他畸形的神经元异位可能难以通过计算机断层扫描诊断。磁共振扫描可能能够显示这些病例。
