Glaze D G, Hrachovy R A, Frost J D, Zion T E, Bryan R N
Department of Neurology, Baylor College of Medicine, Houston, TX 77030.
Pediatr Neurol. 1986 Jan-Feb;2(1):23-7. doi: 10.1016/0887-8994(86)90035-4.
During a prospective double-blind, crossover study of ACTH versus prednisone therapy, serial computed tomography (CT) scans were performed on 16 children with infantile spasms. Pre-treatment scans revealed four findings: normal (6 patients), generalized atrophy (bilaterally enlarged ventricles and/or subarachnoid space) (2 patients), predominantly focal atrophy (3 patients), and congenital anomalies (5 patients). Within 2 weeks of initiating relatively low therapeutic dosages of ACTH or prednisone, a significant number of the infants (63%) had CT findings consistent with decreased cortical volume; in many cases (44%), these findings had not reversed 4 to 6 weeks after discontinuing therapy. Duration of therapy did not correlate significantly with the persistence of CT changes.
在一项关于促肾上腺皮质激素（ACTH）与泼尼松治疗的前瞻性双盲交叉研究中，对16例婴儿痉挛症患儿进行了系列计算机断层扫描（CT）。治疗前扫描显示有四种结果：正常（6例患者）、广泛性萎缩（双侧脑室和/或蛛网膜下腔扩大）（2例患者）、主要为局灶性萎缩（3例患者）和先天性异常（5例患者）。在开始使用相对低治疗剂量的ACTH或泼尼松后的2周内，大量婴儿（63%）的CT结果显示皮质体积减小；在许多病例（44%）中，这些结果在停止治疗4至6周后并未逆转。治疗持续时间与CT改变的持续存在无显著相关性。
