Goto S, Hirano A, Pearson J
Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467.
Acta Neuropathol. 1990;79(6):647-52. doi: 10.1007/BF00294243.
This report concerns the immunohistochemical demonstration of two neuronal Ca2(+)-binding proteins, calcineurin and synaptophysin, in the spinal cord of normal controls and from patients with familial dysautonomia. In controls, calcineurin immunoreactivity was highly concentrated in small nerve cells and fibers of the substantia gelatinosa. Synaptophysin immunoreactivity was normally distributed throughout the spinal cord gray matter, being highly concentrated in the substantia gelatinosa, the dorsal nucleus of Clarke and the anterior horn. In patients with familial dysautonomia, no apparent changes in calcineurin immunoreactivity were found in the substantia gelatinosa. By contrast, there was a significant depletion of synaptophysin-positive axon terminals in the substantia gelatinosa and in the dorsal nucleus of Clarke of patients with familial dysautonomia.
本报告涉及两种神经元钙结合蛋白——钙调神经磷酸酶和突触素在正常对照者及家族性自主神经功能异常患者脊髓中的免疫组织化学显示。在对照者中，钙调神经磷酸酶免疫反应性高度集中于脊髓灰质的小神经细胞和胶状质纤维中。突触素免疫反应性正常分布于整个脊髓灰质，在胶状质、克拉克背核和前角高度集中。在家族性自主神经功能异常患者中，未发现胶状质中钙调神经磷酸酶免疫反应性有明显变化。相比之下，家族性自主神经功能异常患者的胶状质和克拉克背核中，突触素阳性轴突终末显著减少。
