Goto S, Hirano A, Matsumoto S
Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467.
Ann Neurol. 1989 Dec;26(6):766-70. doi: 10.1002/ana.410260613.
A topographical immunocytochemical analysis was performed on the substantia nigra from patients with idiopathic Parkinson's disease and striatonigral degeneration. Antibodies to tyrosine hydroxylase, a marker for nigrostriatal dopaminergic neurons, and to calcineurin, a marker for striatonigral projection fibers, were used in this study. There was a marked depletion of dopaminergic neurons in the substantia nigra of parkinsonian patients compared with control subjects, the reduction being greater in the lateral portion than in the medial portion (p less than 0.001). Calcineurin immunoreactivity was densely distributed throughout the substantia nigra of patients with Parkinson's disease and control subjects. The numbers of dopaminergic neurons and of calcineurin-immunoreactive fibers were markedly reduced in the lateral portion of the substantia nigra in all patients with striatonigral degeneration. Our results suggest that many symptoms of these two diseases may be due to disruption of the functions of the putamen and the lateral portion of the substantia nigra, which have dense reciprocal connections as part of the dopamine-related nigrostriatal loop.
对特发性帕金森病和纹状体黑质变性患者的黑质进行了局部免疫细胞化学分析。本研究使用了针对酪氨酸羟化酶（黑质纹状体多巴胺能神经元的标志物）和钙调神经磷酸酶（纹状体黑质投射纤维的标志物）的抗体。与对照受试者相比，帕金森病患者黑质中的多巴胺能神经元明显减少，外侧部分的减少比内侧部分更明显（p<0.001）。帕金森病患者和对照受试者的整个黑质中钙调神经磷酸酶免疫反应性均呈密集分布。在所有纹状体黑质变性患者中，黑质外侧部分的多巴胺能神经元和钙调神经磷酸酶免疫反应性纤维数量均明显减少。我们的结果表明，这两种疾病的许多症状可能是由于壳核和黑质外侧部分功能的破坏，它们作为多巴胺相关黑质纹状体环路的一部分具有密集的相互连接。
