Life Sciences Institute, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver V6T 1Z3, Canada.
Trends Cell Biol. 2011 Sep;21(9):506-14. doi: 10.1016/j.tcb.2011.04.005. Epub 2011 May 31.
Like the conductor of an orchestra, the Sec protein translocation channel is the platform needed to bring together the many different players required for the constitutive and obligatory process of protein transport. This conserved membrane channel, termed SecY in bacteria and Sec61 in eukaryotes, creates a ubiquitous protein-conducting pathway by which thousands of newly synthesized polypeptides make their way through the lipid bilayer. The channel is not a simple passive pore, however; it displays remarkable complexity by interacting with numerous soluble partners, including SecA, Syd, FtsY and the ribosome in bacteria. For several decades, scientists have been fascinated by the sophistication and versatility of this transport channel. In this review, we cover the current state of the field including some of the newest and most exciting findings on channel structure and mechanism of action.
就像管弦乐队的指挥一样，Sec 蛋白转运通道是一个平台，需要将许多不同的参与者聚集在一起，才能完成蛋白质运输的组成和必需过程。这种保守的膜通道在细菌中称为 SecY，在真核生物中称为 Sec61，它通过一个普遍存在的蛋白质传导途径，使成千上万的新合成多肽穿过脂质双层。然而，该通道并非简单的被动孔道；它通过与许多可溶性伴侣相互作用，包括细菌中的 SecA、Syd、FtsY 和核糖体，显示出显著的复杂性。几十年来，科学家们一直对这种运输通道的复杂性和多功能性着迷。在这篇综述中，我们涵盖了该领域的最新进展，包括关于通道结构和作用机制的一些最新和最令人兴奋的发现。
