Tarayre J P, Lauressergues H
Arch Int Pharmacodyn Ther. 1978 Sep;235(1):165-9.
Phenylbutazone, cyclophosphamide and prednacinolone acetonide, administered around the period of challenge reduced the exudate of pleurisy due to Bordetella pertussis hypersensitivity in the rat. The results on the leukocytes of the exudate are different depending on the class of product studied. Phenylbutazone only slightly reduced the number of mononuclears cells. Both the immunosuppressive and the corticoid induced a clear decrease in the total leukocyte number. But, while prednacinolone effects were nearly equally distributed among mononuclears and polynuclears, cyclophosphamide was mainly active on mononuclears.
在激发期前后给予大鼠保泰松、环磷酰胺和丙酮化泼尼松龙，可减少由百日咳博德特氏菌超敏反应引起的大鼠胸膜炎渗出物。根据所研究产品的类别，渗出液中白细胞的结果有所不同。保泰松仅略微减少单核细胞数量。免疫抑制剂和皮质类固醇均使白细胞总数明显减少。但是，虽然泼尼松龙的作用在单核细胞和多形核细胞中分布几乎相等，但环磷酰胺主要作用于单核细胞。
