Orr W C, Imes N K, Martin R J
Arch Intern Med. 1979 Jan;139(1):109-11.
Seven morbidly obese patients with sleep-related upper airway obstruction (UAO) were studied before and during progesterone treatment. All subjects had severe daytime somnolence, and five of the seven had congestive heart failure. All subjects were studied for one or two consecutive baseline nights in the sleep laboratory. Six of the seven subjects showed a mean of greater than 100 UAOs. Patients were treated for two to four weeks with medroxyprogesterone acetate, 20 mg three times daily. At the end of the treatment period, the sleep studies were repeated. There was no significant difference in the incidence, mean duration, or rate per minute of apneic episodes occurring before and with progesterone treatment. Severe hypoxemia during sleep persisted with treatment, as did the occurrence of cardiac arrhythmias. There was a significant improvement in the waking Pao2 with progesterone treatment.
对7名患有与睡眠相关的上气道阻塞（UAO）的病态肥胖患者在孕酮治疗前和治疗期间进行了研究。所有受试者均有严重的日间嗜睡，7人中有5人患有充血性心力衰竭。所有受试者在睡眠实验室连续进行了1或2个基线夜晚的研究。7名受试者中有6名平均出现超过100次上气道阻塞。患者接受醋酸甲羟孕酮治疗2至4周，每日3次，每次20毫克。在治疗期结束时，重复进行睡眠研究。在孕酮治疗前和治疗期间发生的呼吸暂停事件的发生率、平均持续时间或每分钟发生率没有显著差异。睡眠期间的严重低氧血症在治疗后持续存在，心律失常的发生情况也是如此。孕酮治疗后清醒时的动脉血氧分压有显著改善。
