Conway W A, Zorick F, Piccione P, Roth T
Thorax. 1982 Jan;37(1):49-53. doi: 10.1136/thx.37.1.49.
Nine patients with obstructive sleep apnoea were treated with 5 to 20 mg of protriptyline each night for two to 18 months. In four patients, there was dramatic, sustained improvement in symptoms and measured sleep quality and apnoea frequency and duration. There was no improvement in two patients and three developed intolerable side-effects preventing adequate treatment. Apnoea frequency was the only apparent predictor of responsiveness. Those with fewer than 30 episodes of apnoea per hour consistently improved. Only two of four patients with more than 60 episodes per hour improved. These results provide additional evidence that a carefully monitored trial of protriptyline may benefit selected patients with mild to moderate obstructive sleep apnoea.
九名阻塞性睡眠呼吸暂停患者每晚服用5至20毫克普罗替林，治疗两至18个月。四名患者的症状、测量的睡眠质量、呼吸暂停频率和持续时间有显著且持续的改善。两名患者无改善，三名患者出现无法耐受的副作用，无法进行充分治疗。呼吸暂停频率是唯一明显的反应预测指标。每小时呼吸暂停少于30次的患者持续改善。每小时呼吸暂停超过60次的四名患者中只有两名有所改善。这些结果提供了更多证据，表明对普罗替林进行仔细监测的试验可能会使部分轻至中度阻塞性睡眠呼吸暂停患者受益。
