Cramer H, Renaud B, Billiard M, Mouret J, Hammers R
Arch Psychiatr Nervenkr (1970). 1978 Dec 14;226(3):173-81. doi: 10.1007/BF00341709.
The central metabolism of dopamine, serotonin, cyclic AMP and cyclic GMP was studied by use of the probenecid test in three patients with bismuth encephalopathy and in one patient with mercury encephalopathy. The accumulation of HVA and of cGMP in the cerebrospinal fluid was depressed during the acute phase of bismuth encephalopathy with severe hyposomnia, while it was increased in a patient with regression of clinical symptoms and normal in a patient with more advanced recovery. The patient with chronic mercury poisoning showing a severe cerebellar ataxia and rigidity had an almost complete suppression of HVA accumulation and an increase of cGMP accumulation. No pronounced differences of 5-HIAA and cAMP behavior were found. It is concluded that the central metabolism of dopamine and of cGMP is severely affected in bismuth and mercury encephalopathies.
通过丙磺舒试验，对3例铋中毒性脑病患者和1例汞中毒性脑病患者的多巴胺、5-羟色胺、环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的中枢代谢进行了研究。在铋中毒性脑病急性期伴有严重失眠时，脑脊液中高香草酸（HVA）和cGMP的蓄积受到抑制，而在临床症状消退的患者中其蓄积增加，在恢复较好的患者中则正常。患有慢性汞中毒且表现出严重小脑共济失调和强直的患者，HVA蓄积几乎完全受到抑制，而cGMP蓄积增加。未发现5-羟吲哚乙酸（5-HIAA）和cAMP有明显差异。结论是，铋和汞中毒性脑病严重影响多巴胺和cGMP的中枢代谢。
