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本文引用的文献

1
Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients.南非 HIV 感染患者中 CYP2B6 516G>T 多态性、血浆依非韦伦浓度升高和早期神经精神副作用的存在。
AIDS Res Ther. 2010 Aug 19;7:32. doi: 10.1186/1742-6405-7-32.
2
Efavirenz plasma concentrations at 1, 3, and 6 months post-antiretroviral therapy initiation in HIV type 1-infected South African children.1型人类免疫缺陷病毒感染的南非儿童在抗逆转录病毒治疗开始后1个月、3个月和6个月时的依非韦伦血浆浓度。
AIDS Res Hum Retroviruses. 2010 Jun;26(6):613-9. doi: 10.1089/aid.2009.0200.
3
Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG 5097s).依法韦仑对HIV感染者神经心理表现及症状的长期影响（艾滋病临床试验组5097s研究）
HIV Clin Trials. 2009 Nov-Dec;10(6):343-55. doi: 10.1310/hct1006-343.
4
Is the recommended dose of efavirenz optimal in young West African human immunodeficiency virus-infected children?对于西非感染人类免疫缺陷病毒的年幼儿童，依非韦伦的推荐剂量是否为最佳剂量？
Antimicrob Agents Chemother. 2009 Oct;53(10):4407-13. doi: 10.1128/AAC.01594-08. Epub 2009 Jul 27.
5
Plasma efavirenz concentrations and the association with CYP2B6-516G >T polymorphism in HIV-infected Thai children.泰国感染HIV儿童的血浆依非韦伦浓度及其与CYP2B6-516G>T基因多态性的关联
Antivir Ther. 2009;14(3):315-20.
6
In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function.对CYP2A6功能受损个体中依非韦伦代谢的体内分析。
Pharmacogenet Genomics. 2009 Apr;19(4):300-9. doi: 10.1097/FPC.0b013e328328d577.
7
Antiviral efficacy, tolerability and pharmacokinetics of efavirenz in an unselected cohort of HIV-infected children.依法韦仑在未经过挑选的感染HIV儿童队列中的抗病毒疗效、耐受性及药代动力学
J Antimicrob Chemother. 2008 Jun;61(6):1336-9. doi: 10.1093/jac/dkn112. Epub 2008 Mar 13.
8
Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.一名12岁的HIV阳性女孩出现精神病症状，其依法韦仑血清浓度升高。
Clin Infect Dis. 2007 Nov 15;45(10):e128-30. doi: 10.1086/522764. Epub 2007 Oct 5.
9
High prevalence of subtherapeutic plasma concentrations of efavirenz in children.儿童中依法韦仑血浆浓度低于治疗水平的情况普遍存在。
J Acquir Immune Defic Syndr. 2007 Jun 1;45(2):133-6. doi: 10.1097/QAI.0b013e31805c9d52.
10
Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism.依法韦仑在感染HIV-1的儿童中的药代动力学与CYP2B6-G516T基因多态性相关。
J Acquir Immune Defic Syndr. 2007 Jul 1;45(3):280-5. doi: 10.1097/QAI.0b013e318040b29e.

与依非韦伦起始相关的失神发作。

Absence seizures associated with efavirenz initiation.

机构信息

Empilweni Services and Research Unit (ESRU), Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa.

出版信息

Pediatr Infect Dis J. 2011 Nov;30(11):1001-3. doi: 10.1097/INF.0b013e318223b680.

DOI:10.1097/INF.0b013e318223b680
PMID:21633320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3278073/
Abstract

Efavirenz, used in treating pediatric human immunodeficiency virus infection, has central nervous system side effects. We report on a 5-year-old girl with perinatally acquired human immunodeficiency virus infection, presenting with new onset absence seizures after starting treatment with efavirenz. Plasma efavirenz values were above therapeutic range. The child was homozygous for the CYP2B6-516T/T genotype, which is associated with poor efavirenz clearance. Seizures abated after efavirenz discontinuation.

摘要

依非韦伦，用于治疗儿科人类免疫缺陷病毒感染，具有中枢神经系统副作用。我们报告了一例 5 岁女孩，患有围产期获得的人类免疫缺陷病毒感染，在开始依非韦伦治疗后出现新发失神发作。依非韦伦的血药浓度高于治疗范围。该患儿为 CYP2B6-516T/T 基因型纯合子，与依非韦伦清除率降低相关。停用依非韦伦后癫痫发作停止。