Department of Gastroenterology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
World J Gastroenterol. 2011 May 14;17(18):2343-8. doi: 10.3748/wjg.v17.i18.2343.
To evaluate the association between xeroderma pigmentosum group D (XPD), genetic polymorphism Lys751Gln and esophageal cancer risk.
We searched PubMed up to September 1, 2010 to identify eligible studies. A total of 10 case-control studies including 2288 cases and 4096 controls were included in the meta-analysis. Statistical analysis was performed with Review Manage version 4.2. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.
The results suggested that there is no significant association between XPD Lys751Gln polymorphism and esophageal cancer susceptibility in the overall population. However, in subgroup analysis by histology type, a significant association was found between XPD Lys751Gln polymorphism and esophageal adenocarcinoma (for CC vs AA: OR = 1.25, 95% CI = 1.01-1.55, P = 0.05 for heterogeneity).
Our meta-analysis suggested that XPD Lys751Gln polymorphism may be associated with increased risk of esophageal adenocarcinoma.
评估着色性干皮病组 D（XPD）、遗传多态性 Lys751Gln 与食管癌风险的关联。
我们检索了 PubMed 截至 2010 年 9 月 1 日的相关文献，以确定符合条件的研究。共有 10 项病例对照研究，包括 2288 例病例和 4096 例对照纳入荟萃分析。采用 Review Manager 版本 4.2 进行统计学分析。采用比值比（ORs）及其 95%置信区间（CIs）来评估关联的强度。
结果表明，XPD Lys751Gln 多态性与总体人群食管癌易感性之间无显著关联。然而，按组织学类型进行亚组分析时，XPD Lys751Gln 多态性与食管腺癌之间存在显著关联（CC 与 AA 相比：OR = 1.25，95%CI = 1.01-1.55，P = 0.05 存在异质性）。
本荟萃分析提示 XPD Lys751Gln 多态性可能与食管腺癌风险增加相关。
